Immunoregulatory effects of local and systemic use of melatonin in experimental thermal trauma

High incidence of thermal trauma (TT), increased risk infectious and non-infectious short- long-term complications, limited effectiveness the therapeutic approaches are main pre-requisites for searching pathogenetic justification new therapies. E.g., melatonin, an endogenous homeostatic regulator with pleiotropic properties, deserves special attention. The aim work was to study effect local application (as original dermal film) systemic usage melatonin upon concentrations circulating TNF IL-4 in course experimental trauma.
 rates wound epithelization were expressed as per cent values. plasma IL-4, determined automatic enzyme immunoassay analyzer Personal LAB (Italy).
 In series TT, rate from 5th 20th day experiment. When using films MT TT on days +5, +10 +20, increase registered. Under conditions intraperitoneal injection +20. A correlation analysis revealed stronger interrelations observed when applying trauma, rather than thus suggesting faster repair processes first case, along diminished area alterations decreased amounts cytokines serum.
 blood serum On moderate positive associations recorded between epithelialization concentration cytokines. Upon use increases, decrease negative TNF. DP increases 5, 10 20, decreases serum, +10. correlations IL-4. comparative efficiency MT-containing versus a more accelerated earlier TNF, greater number strength relationships serum.